New approaches to prophylaxis of endometrium hyperplasia relaps in premenopausal women

نویسندگان

چکیده

Research aim: to evaluate the effectiveness of therapy aimed at preventing endometrial hyperplasia recurrence in premenopausal women.Materials and methods. Clinical paraclinical examinations 76 women were carried out. Transvaginal ultrasound was performed, levels estradiol, progesterone, homocysteine, folic acid, serum HOMA index evaluated, body mass blood pressure assessed. Women divided into two groups after histological results obtained: main group included 40 who received oral progestins (dydrogesterone 10 mg) twice a day combination with Depapilin® 395 mg day; comparison 36 only day. Comparison performed 6 9 months start treatment.Results. Endometrial thickness stabilized within group, physiological norm (before treatment – 22 ± 3.1 mm, 8,3 0.46 9,7 0.31 p <0.05). The positive effect consisted significant decrease frequency recurrence, which 17 (17.5%) cases 16 (44.4%) (p also showed stable normalization level estrogen steady homocysteine synergistic increase reduction index.Conclusions. inclusion basic aged is pathogenetically justified due complex drug components on extragonadal estrogens synthesis antiproliferative endometrium.

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ژورنال

عنوان ژورنال: Reproductive Endocrinology

سال: 2021

ISSN: ['2411-1295', '2309-4117']

DOI: https://doi.org/10.18370/2309-4117.2021.58.63-72